MPS Mathematical Sciences Research Programs (MPS MathSci)

The National Science Foundation Directorate for Mathematical and Physical Sciences (NSF MPS) is soliciting proposals for its Mathematical Sciences Research Programs (MPS MathSci). This consolidated initiative funds foundational, theoretical, and applied research across core mathematical domains, including algebra, analysis, topology, computational mathematics, probability, statistics, and mathematical biology. The program prioritizes high-risk, high-reward inquiry capable of expanding human knowledge and reshaping scientific paradigms without requiring immediate commercial applications. Investigator-initiated projects are encouraged to integrate modern technological advancements—such as artificial intelligence, machine learning, and high-performance computation—to uncover new scientific patterns and unlock novel analytical capabilities. In addition to individual and collaborative research, the funding opportunity supports infrastructure initiatives, focused research groups, and training opportunities designed to cultivate early-career researchers and prepare the next generation of mathematical scientists. With an estimated program budget of $200 million, NSF anticipates awarding between 400 and 600 standard or continuing grants. Awards can span up to five years, offering sustained financial backing to reduce administrative overhead and accelerate groundbreaking interdisciplinary research across United States academic and research institutions.